• Paloma Morillas-Sendín, Emilio Delgado-Baeza, María Jesús Delgado-Martos, Mónica Barranco, Juan Francisco del Cañizo, Manuel Ruíz, and Begoña Quintana-Villamandos.
• Department of Anesthesiology and Intensive Care, Gregorio Marañón University General Hospital, 28007 Madrid, Spain.
• Biomed Res Int. 2015 Jan 1; 2015: 898373.

AbstractThe aim of this study was to assess the effect of sevoflurane and propofol on organ blood flow in a porcine model with a left ventricular assist device (LVAD). Ten healthy minipigs were divided into 2 groups (5 per group) according to the anesthetic received (sevoflurane or propofol). A Biomedicus centrifugal pump was implanted. Organ blood flow (measured using colored microspheres), markers of tissue injury, and hemodynamic parameters were assessed at baseline (pump off) and after 30 minutes of partial support. Blood flow was significantly higher in the brain (both frontal lobes), heart (both ventricles), and liver after 30 minutes in the sevoflurane group, although no significant differences were recorded for the lung, kidney, or ileum. Serum levels of alanine aminotransferase and total bilirubin were significantly higher after 30 minutes in the propofol group, although no significant differences were detected between the groups for other parameters of liver function, kidney function, or lactic acid levels. The hemodynamic parameters were similar in both groups. We demonstrated that, compared with propofol, sevoflurane increases blood flow in the brain, liver, and heart after implantation of an LVAD under conditions of partial support.

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