• Acta Neurochir. Suppl. · Jan 1996

    "Small volume resuscitation" as treatment of cerebral blood flow disturbances and increased ICP in trauma and ischemia.

    • O Kempski, C Obert, T Mainka, A Heimann, and U Strecker.
    • Institute for Neurosurgical Pathophysiology, Johannes Gutenberg-Universität Mainz, Federal Republic of Germany.
    • Acta Neurochir. Suppl. 1996 Jan 1;66:114-7.

    Abstract"Small volume resuscitation" (SVR) is a promising concept for the treatment of shock and trauma patients. SVR utilizes the fast infusion of a small volume of hypertonic saline to mobilize intraendothelial and parenchymal water to expand and restitute intravascular volume. Therefore it seems warranted to also consider SVR for the treatment of disturbances of the cerebral circulation and of increased intracranial pressure (ICP). The current study uses a rabbit model of global cerebral ischemia combined with mild hemorrhage to test SVR. Somatosensory evoked potentials (SEPs) serve as a short-term outcome parameter. The data demonstrate a beneficial effect treatment with hypertonic/hyperoncotic saline/hydroxyethylstarch as compared to volume replacement with starch or blood.

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