• Kathmandu Univ Med J (KUMJ) · Jul 2007

    Randomized Controlled Trial Comparative Study

    Comparative study of esmolol and labetalol to attenuate haemodynamic responses after electroconvulsive therapy.

    • S Shrestha, B R Shrestha, C Thapa, S N Pradhan, R Thapa, and S Adhikari.
    • Department of Anaesthesia and IC, Kathmandu Medical College Teaching Hospital, Kathmandu. sanjay_kmcth@yahoo.com
    • Kathmandu Univ Med J (KUMJ). 2007 Jul 1;5(3):318-23.

    ObjectiveThe study was designed to evaluate the hemodynamic effects of Esmolol and labetalol in patients undergoing electroconvulsive therapy.Materials And MethodsNinety patients undergoing electroconvulsive therapy treatment were studied according to randomized, double blind placebo controlled protocol. Ninety patients were divided into three groups with thirty patients in each group. Patients received either Esmolol (1 mg/kg), Labetalol (0.25 mg/kg) or Normal Saline (placebo) intravenously just after induction with propofol. The baseline heart rate and blood pressure were recorded. Hemodynamic parameters before and after drug therapy and after the ECT current application, were recorded at different time intervals.ResultsIt was found that Esmolol significantly attenuated the degree of tachycardia and hypertension after ECT in comparison with placebo in the first three minutes (p<0.05), whereas the rise in HR and blood pressure was significantly blunted in the labetalol group in comparison to placebo, from three minutes onward till ten minutes. (p<0.05).ConclusionIt was concluded that Esmolol is effective in blunting the hemodynamic response after ECT stimulus in the first three minutes after application of the electrical current, whereas Labetalol is effective after five minutes onwards till ten minutes.

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