• Matteo Franchi, Marilù Giacalone, Ippolito Traupe, Rocco Rago, Giacomo Baldi, Francesco Giunta, and Francesco Forfori.
• University of Pisa, 56126 Pisa, Italy. Electronic address: matteoals@gmail.com.
• J Crit Care. 2016 Jun 1; 33: 100-5.

PurposeSeptic shock involves a dysregulation of the immune response to an infection. This may lead to hemodynamic dysfunction and multiple-organ failure. The main aim of this study was to evaluate the effect of coupled plasma filtration adsorption (CPFA) on the hemodynamic profile in patients with septic shock.Materials And MethodsWe retrospectively analyzed data from 21 adult patients admitted to the intensive care unit with a diagnosis of septic shock, comparing data between pre-CPFA and post-CPFA treatment. They received a maximum of 5 cycles of treatment.ResultsCoupled plasma filtration adsorption treatment was associated with a significant increase of mean arterial pressure (P < .001), reduction of the vasoactive/inotropic requirement (P = .007), and renal improvement. In patients with leukocytosis or leucopenia, the leukocyte count was restored to a reference range of values.ConclusionTreatment with CPFA improves hemodynamic parameters in septic shock patients, ameliorating organ failure.Copyright © 2016 Elsevier Inc. All rights reserved.

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