• Kyung Mi Kim, Ki Hwa Lee, Yong Han Kim, Myoung Jin Ko, Jae-Wook Jung, and Eunsu Kang.
• Department of Anaesthesia and Pain Medicine, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea Department of Anaesthesia and Pain Medicine, Kangwon National University, Chuncheon, Republic of Korea.
• J. Int. Med. Res. 2016 Apr 1; 44 (2): 258-66.

ObjectiveA prospective, double-blind, randomized controlled trial to compare the effect of preoperative midazolam or ketamine on the incidence of emergence agitation (EA) following sevoflurane anaesthesia in children.MethodsPaediatric patients (2-6 years old) undergoing ophthalmic surgery were allocated to receive premedication with either 0.1 mg/kg midazolam or 1 mg/kg ketamine. Incidence of EA and postoperative pain scores were recorded at 10-min intervals in the postanaesthetic care unit (PACU). The use of EA rescue medications (fentanyl or midazolam) was recorded.ResultsThe incidence of EA was significantly lower in the ketamine group (n = 33) than the midazolam group (n = 34) at 10 and 20 min after transfer to PACU. There was no significant difference in overall incidence of EA. The frequency of midazolam use as rescue medication was significantly lower in the katamine group than in the midazolam group.ConclusionPremedication with ketamine is more effective than midazolam in preventing EA during the early emergence period after sevoflurane anaesthesia in children.© The Author(s) 2016.

This article appears in the collection: Avoiding post-anesthesia emergence delirium in children.

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