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Int J Clin Pharm Th · Mar 2015
Genotype-based dosage of acenocoumarol in highly-sensitive geriatric patients.
- Roberto Lozano, María-Esther Franco, Luis López, Juan-José Moneva, Vicente Carrasco, and Maria-Angeles Pérez-Layo.
- Int J Clin Pharm Th. 2015 Mar 1;53(3):206-10.
ObjectiveOur aim was to determinate the acenocoumarol dose requirement in highly sensitive geriatric patients, based on a minimum of genotype (VKORC1 and CYP2C9) data.MethodsWe used a Gaussian kernel density estimation test to identify patients highly sensitive to the drug and PHARMACHIP®-Cuma test (Progenika Biopharma, SA, Grifols, Spain) to determine the CYP2C9 and VKORC1 genotype.ResultsAll highly sensitive geriatric patients were taking ≤5.6 mg/week of acenocoumarol (AC), and 86% of these patients presented the following genotypes: CYP2C9*1/*3 or CYP2C9*1/*2 plus VKORC1 A/G, CYP2C9*3/*3, or VKORC1 A/A.ConclusionVKORC1 A and CYP2C9*2 and/or *3 allelic variants extremely influence on AC dose requirement of highly sensitive geriatric patients. These patients display acenocoumarol dose requirement of ≤5.6 mg/week.
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