• Ugeskrift for laeger · Oct 2012

    [No evidence for renal protective effect of loop diuretics for patients having oliguria].

    • Charlotte Runge Sørensen, Jens Kristian Madsen, Frank Schmidt, and Erik Sloth.
    • Anæstesi/intensiv Afdeling I, Aarhus Universitetshospital, Skejby, Brendstrupgårdsvej 100, Aarhus.
    • Ugeskr. Laeg. 2012 Oct 22;174(43):2617-20.

    AbstractIn many intensive care units, loop diuretics are used more or less routinely to achieve a urinary output above 1 ml/kg/h in critically ill patients. We do not in the literature find any basis of this strategy. In contrast, this practice may cause a risk of circulatory instability in the critically ill patient due to large diuresis and volume depletion. There is no evidence so far that the use of loop diuretics has a renal protective effect or any other beneficial impact on the renal function. The use of loop diuretics in oliguric critically ill patients may be harmful. Consequently an individual assessment is required.

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