• Acta Anaesthesiol Scand · Jun 1982

    Randomized Controlled Trial Clinical Trial

    Attenuation of the circulatory response to laryngoscopy and intubation by fentanyl.

    • U M Kautto.
    • Acta Anaesthesiol Scand. 1982 Jun 1;26(3):217-21.

    AbstractThe effects of fentanyl on arterial pressure and heart rate increases during laryngoscopy and intubation were studied in 45 normotensive, surgical patients, who were randomly allocated to three groups receiving 2 or 6 micrograms/kg of fentanyl or saline in a double-blind fashion before anaesthetic induction with thiopental. Fentanyl supplementation with 2 micrograms/kg significantly attenuated the arterial pressure and heart rate increases during laryngoscopy and intubation, and fentanyl, 6 micrograms/kg, completely abolished these responses. Moreover, fentanyl given during the induction decreased the amount of fentanyl needed during the operation. Respiratory depression was not observed during recovery.

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