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- Penelope Bouziotis, Dimitrios Psimadas, Theodoros Tsotakos, Dimosthenis Stamopoulos, and Charalampos Tsoukalas.
- National Center for Scientific Research Demokritos, Patriarchou Grigoriou and Neapoleos Street, 15310 Aghia Paraskevi, Athens, Greece. bouzioti@rrp.demokritos.gr
- Curr Top Med Chem. 2012 Jan 1;12(23):2694-702.
AbstractDual-modality contrast agents, such as radiolabeled nanoparticles, are promising candidates for a number of diagnostic applications, since they combine the advantages of two different imaging modalities, namely SPECT or PET imaging with MR imaging. The benefit of such a combination is to more accurately interpret disease and abnormalities in vivo, by exploiting the advantages of each imaging technique, i.e. high sensitivity for SPECT/PET, high resolution anatomical information for MRI. In this review article, we provide an overview of recent findings in the synthesis, evaluation and application of radiolabeled iron oxide nanoparticles as dual-modality SPECT/MRI and PET/MRI imaging probes.
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