• Der Anaesthesist · May 1997

    Review

    [The clinical pharmacology of mivacurium].

    • C Diefenbach and H Mellinghoff.
    • Klinik und Poliklinik für Anästhesiologie und Operative Intensivmedizin, Universität zu Köln.
    • Anaesthesist. 1997 May 1; 46 (5): 385-8.

    AbstractMivacurium is a short-acting, nondepolarising muscle relaxant of the benzylisoquinoline type that undergoes rapid breakdown by plasma cholinesterase. After 2.5 times the ED95 (0.2 mg/kg), tracheal intubation can be accomplished within 2-3 min following injection. The ensuing DUR 25% (i.e., time from injection to 25% recovery of control twitch tension) is three times as long as with succinylcholine. The principal side effects of mivacurium are facial flushing and a transient fall in blood pressure due to moderate histamine release following doses 3-4 times the ED95. In patients with end-stage liver or renal disease as well as those with atypical plasma cholinesterase, the duration of action of mivacurium is prolonged.

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