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Blood Coagul. Fibrinolysis · May 2004
ReviewRole of the tissue factor pathway in the pathogenesis and management of multiple organ failure.
- Mark N Smithies and Christine B Weaver.
- Critical Care Services, Cardiff & Vale NHS Trust, Wales, UK. mark.smithies@cardiffandvale.wales.nhs.uk
- Blood Coagul. Fibrinolysis. 2004 May 1;15 Suppl 1:S11-20.
AbstractSepsis is caused by a dysregulated immune response to infection and, without intervention, can lead to septic shock and multiple organ failure. A leading cause of morbidity and mortality in intensive care units worldwide, severe sepsis is also associated with a considerable cost burden that places significant strain on global healthcare budgets. The development of an efficacious and cost-effective treatment strategy is therefore of vital importance to today's intensive care physicians. This paper will examine the pathophysiology of sepsis and multiple organ dysfunction before reviewing trials recently undertaken to investigate three potential anticoagulant therapies: antithrombin III, activated protein C, and tissue factor pathway inhibitor. Finally, other recent developments in the care of sepsis patients will be briefly examined.
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