• Expert Rev Clin Pharmacol · Jan 2016

    Review

    Buprenorphine - the unique opioid adjuvant in regional anesthesia.

    • Juliusz Kosel, Piotr Bobik, and Michał Tomczyk.
    • a Department of Anesthesiology and Intensive Therapy, Faculty of Medicine with the Division of Dentistry and Division of Medical Education in English , Medical University of Białystok , Białystok , Poland.
    • Expert Rev Clin Pharmacol. 2016 Jan 1; 9 (3): 375-83.

    AbstractRegional anesthesia techniques are commonly used for many surgical procedures alone or as an addition to general anesthesia, because they offer many advantages over general anesthesia. Unfortunately these techniques are partially limited by the time of action of local anesthetics. One of the methods of overcoming this limitation is adding to the local anesthetic solution additional drug--so called adjuvant. Among many adjuvants to local anesthetic drugs tested so far one seems to be particularly interesting--buprenorphine. The aim of this paper is to present pharmacological background for using buprenorphine for regional anesthesia and to review clinical trials of using buprenorphine for all regional anesthesia techniques: spinal and epidural anesthesia, peripheral nerves blocks, local anesthesia and intravenous regional anesthesia.

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