-
Randomized Controlled Trial
The post-tetanic count during vecuronium-induced neuromuscular blockade in halothane-anaesthetized dogs.
- Farshid Sarrafzadeh-Rezaei and R Eddie Clutton.
- Department of Clinical Sciences, University of Urmia, Western Azerbaijan, Iran.
- Vet Anaesth Analg. 2009 May 1;36(3):246-54.
ObjectiveTo evaluate the post-tetanic count (PTC) for predicting the return of reversible neuromuscular blockade at the n. facialis-m. nasolabialis (nF-mNL) and n. ulnaris-mm. carpi flexorii (nU-mCF) nerve-muscle units (NMUs) during profound vecuronium neuromuscular blockade in halothane-anaesthetized dogs.Study DesignRandomized, prospective, experimental study.AnimalsTwenty-five dogs (seven male 18 female) undergoing surgery; mean age: 4.8 years; mean body weight 22 kg.MethodsThirty minutes after acepromazine (0.05 mg kg(-1)) and morphine (0.5 mg kg(-1)) pre-medication, anaesthesia was induced with intravenous (IV) thiopental and maintained with halothane, N(2)O and O(2). The lungs were mechanically ventilated and end-tidal halothane concentration (Fe'(HAL)) maintained at 1.04%. Neuromuscular transmission was monitored using the train-of-four count (TOFC) at one nF-mNL and both nU-mCF units. Vecuronium (50 microg kg(-1) IV) was injected after 15 minutes constant Fe'(HAL). When the first twitch (T1) at both nU-mCF units had disappeared (t = 0) one (randomly allocated) ulnar nerve was stimulated every 5 minutes using PTC; TOF stimulation continued at the other sites. The PTC was plotted against the interval between recording time and T1's reappearance at the other NMUs.ResultsAt t = 0, the mean PTC in the contralateral nU-mCF unit was 18 (range 0-20). Mean PTC was a minimum at t = 5, rising to the maximum (20) at 25 minutes. Six dogs were vecuronium-resistant as monitored by PTC. Excluding data from these revealed a strong negative relationship between ulnar PTC and the time taken for T1's return at the facial (r = -0.7018; p < 0.00001) and contralateral ulnar (r = -0.8409; p < 0.00001) NMUs.Conclusion And Clinical RelevancePost-tetanic count monitoring beginning >5 minutes after the TOFC at nU-mCF = 0 provided a reliable estimate of T1's return at ulnar and facial NMUs.
Notes
Knowledge, pearl, summary or comment to share?You can also include formatting, links, images and footnotes in your notes
- Simple formatting can be added to notes, such as
*italics*
,_underline_
or**bold**
. - Superscript can be denoted by
<sup>text</sup>
and subscript<sub>text</sub>
. - Numbered or bulleted lists can be created using either numbered lines
1. 2. 3.
, hyphens-
or asterisks*
. - Links can be included with:
[my link to pubmed](http://pubmed.com)
- Images can be included with:
![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
- For footnotes use
[^1](This is a footnote.)
inline. - Or use an inline reference
[^1]
to refer to a longer footnote elseweher in the document[^1]: This is a long footnote.
.