• Swiss medical weekly · Nov 1988

    Randomized Controlled Trial Clinical Trial

    [Systemic thrombolysis using streptokinase. Experiences at the Civic Hospital of Lugano in the framework of the ISIS-2 study].

    • T Moccetti, M Rezzonico, F Clara, A Riva, F Tanzi, M Genoni, and R Malacrida.
    • Clinica Medica Ospedale Civico Lugano.
    • Swiss Med Wkly. 1988 Nov 19;118(46):1702-5.

    AbstractWith a small group of Swiss hospitals we had an opportunity of participating in ISIS-2, the major study on thrombolysis in acute myocardial infarction. Experience with our microcosm (Ospedale Civico Lugano) was compared with the macrocosm of the results of ISIS-2 in 17,187 randomized patients (in brackets). Mortality was 5.1% (7.8%) in our streptokinase group and 15.8% (12.8%) in our placebo group. In the ISIS-2 study the combination of thrombolytic therapy with streptokinase, and of antiplatelet therapy with aspirin, showed a reduction of approximately one third in acute mortality of myocardial infarction, stroke and reinfarction. Our experience confirms the reduced incidence of allergic side effects (3.5%), major bleeding (0.3%) and minor bleeding (2.9%) during or after thrombolytic therapy.

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