[Oxytocin in cesarean-sections. What's new?]

Rev Bras Anestesiol · Jul 2016

[Oxytocin in cesarean-sections. What's new?]

Oxytocin is the uterotonic agent of choice in the prevention and treatment of postpartum uterine atony. Nevertheless, there is no consensus on the optimal dose and rate for use in cesarean sections. The use of high bolus doses (e.g., 10 IU of oxytocin) can determine deleterious cardiovascular changes for the patient, especially in situations of hypovolemia or low cardiac reserve. Furthermore, high doses of oxytocin for prolonged periods may lead to desensitization of oxytocin receptors in myometrium, resulting in clinical inefficiency.

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- Eduardo Tsuyoshi Yamaguchi, Mônica Maria Siaulys, and Marcelo Luis Abramides Torres.
- Hospital Universitário da Universidade de São Paulo (HU-USP), São Paulo, SP, Brasil. Electronic address: eduardo@hu.usp.br.
- Rev Bras Anestesiol. 2016 Jul 1; 66 (4): 402-7.
AbstractOxytocin is the uterotonic agent of choice in the prevention and treatment of postpartum uterine atony. Nevertheless, there is no consensus on the optimal dose and rate for use in cesarean sections. The use of high bolus doses (e.g., 10 IU of oxytocin) can determine deleterious cardiovascular changes for the patient, especially in situations of hypovolemia or low cardiac reserve. Furthermore, high doses of oxytocin for prolonged periods may lead to desensitization of oxytocin receptors in myometrium, resulting in clinical inefficiency.Copyright © 2015 Sociedade Brasileira de Anestesiologia. Publicado por Elsevier Editora Ltda. All rights reserved.

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[Oxytocin in cesarean-sections. What's new?]

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