• Curr. Opin. Neurobiol. · Jun 2012

    Review

    Regulation of AMPA receptor trafficking and synaptic plasticity.

    • Victor Anggono and Richard L Huganir.
    • Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States.
    • Curr. Opin. Neurobiol. 2012 Jun 1;22(3):461-9.

    AbstractAMPA receptors (AMPARs) mediate the majority of fast excitatory synaptic transmission in the brain. Dynamic changes in neuronal synaptic efficacy, termed synaptic plasticity, are thought to underlie information coding and storage in learning and memory. One major mechanism that regulates synaptic strength involves the tightly regulated trafficking of AMPARs into and out of synapses. The life cycle of AMPARs from their biosynthesis, membrane trafficking, and synaptic targeting to their degradation are controlled by a series of orchestrated interactions with numerous intracellular regulatory proteins. Here we review recent progress made toward the understanding the regulation of AMPAR trafficking, focusing on the roles of several key intracellular AMPAR interacting proteins.Copyright © 2011 Elsevier Ltd. All rights reserved.

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