• J R Cerhan, A R Folsom, J D Potter, and R J Prineas.
• Division of Epidemiology, University of Minnesota School of Public Health, Minneapolis 55454.
• Am. J. Epidemiol. 1994 Aug 15;140(4):368-74.

AbstractLeft-handedness has been associated with decreased longevity, although this finding is controversial and not universal. The authors prospectively studied 39,691 women aged 55-69 years from the Iowa Women's Health Study through 5 years of mortality follow-up. No increase in mortality risk was found for left-handed women as compared with right-handed women (age-adjusted hazard ratio 1.10, 95% confidence interval (CI) 0.86-1.39) or for ambidextrous women (age-adjusted hazard ratio 1.05, 95% CI 0.73-1.49). Adjustment for body mass index, body fat distribution, smoking, and education did not alter these findings. Further analysis by cause-specific mortality (breast cancer, all other cancer, and circulatory disease) showed no relation to handedness. There was no difference in the mean age at death of left-handed, right-handed, and ambidextrous women. These findings do not support an association between left-handedness and increased mortality risk.

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