• Marco Simonini, Chiara Lanzani, Elena Bignami, Nunzia Casamassima, Elena Frati, Roberta Meroni, Elisabetta Messaggio, Ottavio Alfieri, John Hamlyn, Simon C Body, C David Collard, Alberto Zangrillo, Paolo Manunta, and CABG Genomics Investigators.
• Chair of Nephrology, Università Vita Salute San Raffaele, Milan, Italy Genomics of Renal Disease and Hypertension Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
• Nephrol. Dial. Transplant. 2014 Sep 1;29(9):1696-701.

BackgroundAcute kidney injury (AKI) is an important complication of cardiac surgery. Recently, elevated levels of endogenous ouabain (EO), an adrenal stress hormone with haemodynamic and renal effects, have been associated with worse renal outcome after cardiac surgery. Our aim was to develop and evaluate a new risk model of AKI using simple preoperative clinical parameters and to investigate the utility of EO.MethodsThe primary outcome was AKI according to Acute Kidney Injury Network stage II or III. We selected the Northern New England Cardiovascular Disease Study Group (NNECDSG) as a reference model. We built a new internal predictive risk model considering common clinical variables (CLIN-RISK), compared this model with the NNECDSG model and determined whether the addition of preoperative plasma EO improved prediction of AKI.ResultsAll models were tested on >800 patients admitted for elective cardiac surgery in our hospital. Seventy-nine patients developed AKI (9.9%). Preoperative EO levels were strongly associated with the incidence of AKI and clinical complication (total ICU stay and in-hospital mortality). The NNECDSG model was confirmed as a good predictor of AKI (AUC 0.74, comparable to the NNECDSG reference population). Our CLIN-RISK model had improved predictive power for AKI (AUC 0.79, CI 95% 0.73-0.84). Furthermore, addition of preoperative EO levels to both clinical models improved AUC to 0.79 and to 0.83, respectively (ΔAUC +0.05 and +0.04, respectively, P < 0.01).ConclusionIn a population where the predictive power of the NNECDSG model was confirmed, CLIN-RISK was more powerful. Both clinical models were further improved by the addition of preoperative plasma EO levels. These new models provide improved predictability of the relative risk for the development of AKI following cardiac surgery and suggest that EO is a marker for renal vascular injury.© The Author 2014. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.

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