• W C Huskins, K Ba-Thike, M R Festin, S Limpongsanurak, P Lumbiganon, A Peedicayil, M Purwar, S Shenoy, D A Goldmann, J E Tolosa, and Global Network for Perinatal and Reproductive Health.
• Mayo Medical School, MN, Rochester, USA. huskins.charles@mayo.edu
• Int J Gynaecol Obstet. 2001 May 1;73(2):141-5.

ObjectiveTo examine the use of antibiotic prophylaxis in cesarean section in different countries and in relation to a reference regimen.MethodFifty consecutive cesarean sections performed in eight centers in five countries were surveyed. Data from each center were compared to a regimen recommended by the Cochrane Collaboration (one dose of ampicillin or cefazolin administered to all women shortly before the procedure or immediately after cord clamping) using logistic regression with adjustment for procedure type.ResultProphylaxis was used widely, but only four centers administered prophylaxis to all women. Ampicillin and cefazolin were the principal antibiotics used, but broad-spectrum agents and multidrug regimens were also used commonly. Only two centers reliably administered the antibiotic at the appropriate time. The majority of women received only one dose of antibiotic in only three centers.ConclusionThe use of antibiotic prophylaxis in cesarean section was variable and often at odds with published recommendations.

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