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- Peng Sun, Katherine N Maloney, Sang-Jip Nam, Nina M Haste, Ritesh Raju, William Aalbersberg, Paul R Jensen, Victor Nizet, Mary E Hensler, and William Fenical.
- Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093-0204, USA.
- Bioorg. Med. Chem. 2011 Nov 15;19(22):6557-62.
AbstractThree new depsipeptides, fijimycins A-C (1-3), together with the known etamycin A (4), were isolated and identified from the fermentation broth of strain CNS-575, a Streptomyces sp. cultured from a marine sediment sample collected off Nasese, Fiji. The planar structures of the new fijimycins were assigned by combined interpretation of NMR and MS/MS spectroscopic data. These assignments were complicated by the fact that 1-3 occurred as complex amide conformational mixtures. The absolute configurations of the component amino acids were established using the Marfey's method. Fijimycins A-C, and etamycin A, were shown to possess significant in vitro antibacterial activity against three methicillin-resistant Staphylococcus aureus (MRSA) strains with MIC(100) values between 4 and 16 μg mL(-1).Copyright © 2011 Elsevier Ltd. All rights reserved.
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