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Randomized Controlled Trial Comparative Study Clinical Trial
Onset and recovery of rocuronium (Org 9426) and vecuronium under enflurane anaesthesia.
- M Mayer, A Doenicke, A Hofmann, and K Peter.
- Institute of Anaesthesiology, LMU München, Innenstadtkliniken, Germany.
- Br J Anaesth. 1992 Nov 1;69(5):511-2.
AbstractWe have studied the onset, duration of action and recovery index of twice the ED90 of rocuronium (Org 9426) (0.6 mg kg-1) and of vecuronium (0.08 mg kg-1) in patients during enflurane anaesthesia. Rocuronium had a significantly shorter mean onset time of 1.8 (SD 0.4) min, compared with vecuronium 3.4 (0.8) min. Clinical duration (time for the first twitch in the train-of-four to recover to 25% of control) was similar for both drugs (29 (10) min vs 31 (12) min). Spontaneous recovery times (TOF ratio 70%) did not differ significantly between rocuronium (47 (10) min) and vecuronium (44 (11) min).
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