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Neuromuscul. Disord. · Jul 2007
Quantitative skeletal muscle ultrasound: diagnostic value in childhood neuromuscular disease.
- S Pillen, A Verrips, N van Alfen, I M P Arts, L T L Sie, and M J Zwarts.
- Department of Clinical Neurophysiology, Institute of Neurology, Neuromuscular Centre Nijmegen, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. s.pillen@cukz.umcn.nl
- Neuromuscul. Disord. 2007 Jul 1;17(7):509-16.
UnlabelledIn this study we investigated the diagnostic value of quantitative skeletal muscle ultrasonography in 150 consecutively referred children with symptoms suspect for a neuromuscular disorder. Muscle thickness and quantitatively determined echo intensity of four muscles and the distribution of these variables within the body were examined.ResultsPatients with and without a neuromuscular disorder could be discriminated with a positive predictive value of 91% and a negative predictive value of 86%. Patients with a neurogenic disorder could be distinguished from myopathies and non-neuromuscular disorders with a positive predictive value of 86% and a negative predictive of 84%, using the pattern of distribution of pathology within the body.ConclusionsSkeletal muscle ultrasound is a good, practical and non-invasive aid in the diagnosis of neuromuscular disorders in children, that is able to discriminate between children with and without a neuromuscular disorder and between neurogenic disorders and myopathies with high predictive values.
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