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- Geórgea Hermogenes Fernandes, Edmar Zanoteli, and Samuel Katsuyuki Shinjo.
- Division of Rheumatology, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo , São Paulo , Brazil.
- Mod Rheumatol. 2014 Sep 1;24(5):862-4.
AbstractNecrotizing autoimmune myopathy (NAM) is a severe adverse effect of statins. We report a 66-year-old Caucasian female who had progressive proximal muscle weakness after treatment with statins. Results of a muscle biopsy showed necrotizing myopathy with minimal inflammatory cell infiltrate and increased major histocompatibility class I antigen expression in muscle fibers. The clinical and laboratory parameters improved significantly with immunosuppressive treatment. Although it is a rare event, statin-induced NAM should be included as a differential diagnosis of myopathies.
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