• Carlos Marquez de la Plata, Andreea Ardelean, Della Koovakkattu, Priya Srinivasan, Anna Miller, Viet Phuong, Caryn Harper, Carol Moore, Anthony Whittemore, Christopher Madden, Ramon Diaz-Arrastia, and Michael Devous.
• Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9036, USA. Carlos.MarquezdelaPlata@UTSouthwestern.edu
• J. Neurotrauma. 2007 Apr 1;24(4):591-8.

AbstractDiffuse axonal injury (DAI) is a common mechanism of traumatic brain injury (TBI) for which there is no well-accepted anatomic measures of injury severity. The present study aims to quantitatively assess DAI by measuring white matter lesion volume visible in fluid-attenuated inversion recovery (FLAIR) weighted images and to determine whether higher lesion volumes are associated with unfavorable functional outcome 6 months after injury. Twenty-four patients who experienced moderate to severe TBI without extra-axial or major cortical contusions were included in this study. Lesion volume was assessed by quantifying areas of hyperintensities in the white matter utilizing digitized FLAIR images. Two independent raters processed the magnetic resonance (MR) images and determined the total DAI volume. Functional outcome was assessed at 6 months after injury using the Glasgow Outcome Scale-Extended (GOSE). Interclass correlation analyses showed very high interrater reliability for each measure between the two raters (Interclass Correlation Coefficient = 0.95, p

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