• Joanne M Wrench, Sarah J Wilson, Marie F O'Shea, and David C Reutens.
• School of Behavioural Science, University of Melbourne, Melbourne, Victoria 3010, Australia. joanne.wrench@unimelb.edu.au
• Epilepsy Res. 2009 Jan 1;83(1):81-8.

AbstractDe novo depression is a common psychiatric sequelae of epilepsy surgery. To date, no studies have described possible clinical correlates of de novo depression in this population. This qualitative study presents a detailed analysis of five cases of de novo depression. Data were collected from patients' medical files and routine in-depth psychosocial and psychiatric interviews (the Austin CEP Interview). All patients who developed de novo depression underwent anterior temporal lobectomy (ATL). Four out of five cases occurred within the first 3 months following surgery, and all were preceded by significant post-operative irritability reported by the patient's family. All experienced post-operative marital/relationship conflict that appeared to be a catalyst for deteriorating mood. Post-operative seizures were not temporally linked to the onset of depressive symptoms. This series provides an initial account of factors associated with de novo depression following anterior temporal lobectomy and may be of use in guiding larger scale studies.

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