• Life sciences · Jun 2015

    NSAIDs induce peripheral antinociception by interaction with the adrenergic system.

    • Lívia Caroline Resende Silva, Marina Gomes Miranda e Castor, Tâmara Cristina Souza, Igor Dimitri Gama Duarte, and Thiago Roberto Lima Romero.
    • Department of Pharmacology, Institute of Biological Sciences, ICB-UFMG, Av. Antônio Carlos, 6627, Pampulha, CEP 31.270-100 Belo Horizonte, MG, Brazil.
    • Life Sci. 2015 Jun 1;130:7-11.

    AimsWe evaluated the role of adrenergic systems on the peripheral antinociception induced by dipyrone and diclofenac. Mainmethods: The rat pawpressure test, inwhich sensitivity is increased by intraplantar injection of prostaglandin E2, was used to examine the peripheral effects of locally administered drugs.Key FindingsDipyrone (10, 20 and 40 μg) and diclofenac (5, 10 and 20 μg) administered locally into the right paw elicited a dose-dependent antinociceptive effect, which was demonstrated to be local; the injection of drugs into the ipsilateral and contralateral hindpaws demonstrated an effect only in the ipsilateral paw because only the treated paw produced an antinociceptive effect. To test the adrenergic system, we used guanethidine (30 mg/kg) to deplete noradrenalin from noradrenergic vesicles. Guanethidine antagonized the peripheral antinociception induced by diclofenac and dipyrone. Yohimbine (2.5, 5, 10, or 20 μg/paw) a nonselective α2-adrenergic receptor antagonist antagonized the peripheral antinociception induced by diclofenac (20 μg/paw) and dipyrone (40 μg/paw). Rauwolscine (Rau; 10, 15, 20 μg), a selective α2C-adrenoreceptor, was able to block the peripheral antinociception induced by NSAIDs. The other specific α2A,B and D-adrenoreceptor antagonists (BRL 44480, imiloxan and RX 821002, respectively) did not modify the peripheral antinociception. However, prazosin (0.5, 1, and 2 μg/paw), an α1 receptor antagonist, and propranolol (0.3, 0.6 or 1.2 μg/paw), a β-adrenoreceptor antagonist, antagonized the antinociception induced by diclofenac (20 μg/paw) and dipyrone (40 μg/paw).SignificanceDipyrone and diclofenac produce peripheral antinociception, which involves the release of NA and interaction with α1, α2C and β-adrenoreceptors.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…