Mediators of systemic inflammatory response syndrome and the

Infect. Dis. Clin. North Am. · Dec 2011

Review

Mediators of systemic inflammatory response syndrome and the role of recombinant activated protein C in sepsis syndrome.

The systemic inflammatory response syndrome, the host's response to infection involves a series of cascading events that mobilize a series of mediators involving the immune system, complement, and the coagulation cascade. Although the initial focus of mediators is to limit infection, this cascade may run amok and cause the development of hypotension, vascular instability, and disseminated intravascular coagulation, leading to morbidity and mortality in the host. Several therapeutic trials have focused on the modulation of these mediators, but use of recombinant human activated protein C in patients with severe sepsis is the only one that has shown a benefit in clinical trials.

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- Vivek Kak.
- Infectious Diseases, Allegiance Health, Jackson, MI 49201, USA. vkak@yahoo.com
- Infect. Dis. Clin. North Am. 2011 Dec 1;25(4):835-50.
AbstractThe systemic inflammatory response syndrome, the host's response to infection involves a series of cascading events that mobilize a series of mediators involving the immune system, complement, and the coagulation cascade. Although the initial focus of mediators is to limit infection, this cascade may run amok and cause the development of hypotension, vascular instability, and disseminated intravascular coagulation, leading to morbidity and mortality in the host. Several therapeutic trials have focused on the modulation of these mediators, but use of recombinant human activated protein C in patients with severe sepsis is the only one that has shown a benefit in clinical trials.Copyright Â© 2011 Elsevier Inc. All rights reserved.

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Mediators of systemic inflammatory response syndrome and the role of recombinant activated protein C in sepsis syndrome.

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