• Jennifer M Andresen, Timothy D Girard, Pratik P Pandharipande, Mario A Davidson, E Wesley Ely, and Paula L Watson.
• 1Department of Pediatrics, Children's Hospital of Pittsburgh, Pittsburgh, PA. 2Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN. 3Center for Health Services Research, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN. 4Geriatric Research, Education, and Clinical Center Service, Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, TN. 5Anesthesia Service, Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, TN. 6Division of Critical Care, Department of Anesthesia, Vanderbilt University Medical Center, Nashville, TN. 7Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN.
• Crit. Care Med. 2014 Oct 1; 42 (10): 2244-51.

ObjectivesMany patients, due to a combination of illness and sedatives, spend a considerable amount of time in a comatose state that can include time in burst suppression. We sought to determine if burst suppression measured by processed electroencephalography during coma in sedative-exposed patients is a predictor of post-coma delirium during critical illness.DesignObservational convenience sample cohort.SettingMedical and surgical ICUs in a tertiary care medical center.PatientsCohort of 124 mechanically ventilated ICU patients.InterventionsNone.Measurements And Main ResultsDepth of sedation was monitored twice daily using the Richmond Agitation-Sedation Scale and continuously monitored by processed electroencephalography. When noncomatose, patients were assessed for delirium twice daily using Confusion Assessment Method for the ICU. Multiple logistic regression and Cox proportional hazards regression were used to assess associations between time in burst suppression and both prevalence and time to resolution of delirium, respectively, adjusting for time in deep sedation and a principal component score consisting of Acute Physiology and Chronic Health Evaluation II score and cumulative doses of sedatives while comatose. Of the 124 patients enrolled and monitored, 55 patients either never had coma or never emerged from coma, yielding 69 patients for whom we performed these analyses; 42 of these 69 (61%) had post-coma delirium. Most patients had burst suppression during coma, although often short-lived (median [interquartile range] time in burst suppression, 6.4 [1-58] min). After adjusting for covariates, even this short time in burst suppression independently predicted a higher prevalence of post-coma delirium (odds ratio, 4.16; 95% CI, 1.27-13.62; p = 0.02) and a lower likelihood (delayed) resolution of delirium (hazard ratio, 0.78; 95% CI, 0.53-0.98; p = 0.04).ConclusionsTime in burst suppression during coma, as measured by processed electroencephalography, was an independent predictor of prevalence and time to resolution of postcoma/post-deep sedation delirium. These findings of this single-center investigation support lighter sedation strategies.

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