• Thomas W Buford.
• Department of Aging and Geriatric Research, University of Florida, Gainesville, FL 32611, USA. Electronic address: tbuford@ufl.edu.
• Ageing Res. Rev. 2016 Mar 1; 26: 96-111.

AbstractHypertension is a highly prevalent condition with numerous health risks, and the incidence of hypertension is greatest among older adults. Traditional discussions of hypertension have largely focused on the risks for cardiovascular disease and associated events. However, there are a number of collateral effects, including risks for dementia, physical disability, and falls/fractures which are increasingly garnering attention in the hypertension literature. Several key mechanisms--including inflammation, oxidative stress, and endothelial dysfunction--are common to biologic aging and hypertension development and appear to have key mechanistic roles in the development of the cardiovascular and collateral risks of late-life hypertension. The objective of the present review is to highlight the multi-dimensional risks of hypertension among older adults and discuss potential strategies for treatment and future areas of research for improving overall care for older adults with hypertension.Copyright © 2016 Elsevier B.V. All rights reserved.

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