• K Y R Kam, J M Mari, and T J Wigmore.
• Magill Department of Anaesthesia, Intensive Care and Pain Management, Imperial College London, Chelsea and Westminster Hospital, London, UK. ronald.kam02@imperial.ac.uk
• Anaesthesia. 2012 Feb 1;67(2):115-21.

AbstractDual-lumen haemodiafiltration catheters enable continuous renal replacement therapy in the critically ill and are often co-located with central venous catheters used to infuse drugs. The extent to which infusions are immediately aspirated by an adjacent haemodiafiltration catheter remains unknown. A bench model was constructed to evaluate this effect. A central venous catheter and a haemodiafiltration catheter were inserted into a simulated central vein and flow generated using centrifugal pumps within the simulated vein and haemodiafiltration circuit. Ink was used as a visual tracer and creatinine solution as a quantifiable tracer. Tracers were completely aspirated by the haemodiafiltration catheter unless the infusion was at least 1 cm downstream to the arterial port. No tracer was aspirated from catheters infusing at least 2 cm downstream. Orientation of side ports did not affect tracer elimination. Co-location of central venous and haemodiafiltration catheters may lead to complete aspiration of infusions into the haemodiafilter with resultant drug under-dosing.Anaesthesia © 2011 The Association of Anaesthetists of Great Britain and Ireland.

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