• Jeremy Koppel, Terry E Goldberg, Marc L Gordon, Edward Huey, Peter Davies, Linda Keehlisen, Sara Huet, Erica Christen, and Blaine S Greenwald.
• The Litwin-Zucker Research Center for the Study of Alzheimer's Disease and Memory Disorders, The Feinstein Institute for Medical Research, The North Shore-Long Island Jewish Health System, Manhasset, NY, USA. jkoppel@lij.edu
• Am J Geriatr Psychiatry. 2012 Nov 1;20(11):994-1000.

ObjectivesBehavioral disturbances occur in nearly all Alzheimer disease (AD) patients together with an array of cognitive impairments. Prior investigations have failed to demonstrate specific associations between them, suggesting an independent, rather than shared, pathophysiology. The objective of this study was to reexamine this issue using an extensive cognitive battery together with a sensitive neurobehavioral and functional rating scale to correlate behavioral syndromes and cognitive domains across the spectrum of impairment in dementia.DesignCross-sectional study of comprehensive cognitive and behavioral ratings in subjects with AD and mild cognitive impairment.SettingMemory disorders research center.ParticipantsFifty subjects with AD and 26 subjects with mild cognitive impairment; and their caregivers.MeasurementsCognitive rating scales administered included the Mini-Mental State Examination; the Modified Mini-Mental State Examination; the Boston Naming Test; the Benton Visual Retention Test; the Consortium to Establish a Registry for Alzheimer's Disease Neuropsychology Assessment; the Controlled Oral Word Test; the Wechsler Memory Scale logical memory I and logical memory II task; the Wechsler Memory Scale-Revised digit span; the Wechsler Adult Intelligence Scale-Revised digit symbol task; and the Clock Drawing Task together with the Clinical Dementia Rating Scale and the Neuropsychiatric Inventory.ResultsStepwise regression of cognitive domains with symptom domains revealed significant associations of mood with impaired executive function/speed of processing (Δr = 0.22); impaired working memory (Δr = 0.05); impaired visual memory (Δr = 0.07); and worsened Clinical Dementia Rating Scale (Δr = 0.08). Psychosis was significantly associated with impaired working memory (Δr = 0.13).ConclusionsMood symptoms appear to impact diverse cognitive realms and to compromise functional performance. Among neuropsychological indices, the unique relationship between working memory and psychosis suggests a possible common underlying neurobiology.2012 American Association for Geriatric Psychiatry

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