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Anaesth Intensive Care · Jun 1996
Comparative StudyPostoperative nausea and vomiting. Propofol or thiopentone: does choice of induction agent affect outcome?
- P S Myles, M Hendrata, A M Bennett, M Langley, and M R Buckland.
- Department of Anaesthesia and Pain Management, Alfred Hospital, Melbourne, Victoria.
- Anaesth Intensive Care. 1996 Jun 1;24(3):355-9.
AbstractPostoperative nausea and vomiting (PONV) has many causes, including anaesthetic drugs. Choice of induction agent may affect the incidence of PONV, though the evidence is conflicting. We have analysed our database of outcome after surgery. Data on 4173 patients were analysed using multivariate logistic regression, with an overall incidence of PONV 21.3%. Propofol, when compared to thiopentone for induction of anaesthesia, resulted in an 18% reduction in PONV (OR = 0.82, P = 0.03). The likely postoperative benefits of propofol may outweigh concerns about its additional cost.
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