• Agents Actions Suppl. · Jan 1992

    The bradykinin antagonist Hoe 140 inhibits carrageenan- and thermically induced paw oedema in rats.

    • K J Wirth, H G Alpermann, R Satoh, and M Inazu.
    • Hoechst AG, Frankfurt, FRG.
    • Agents Actions Suppl. 1992 Jan 1;38 ( Pt 3):428-31.

    AbstractThe new and highly potent B2 bradykinin (BK) antagonist Hoe 140 was tested for its ability to inhibit oedema of rat paws induced by scalding and carrageenan. The data show that Hoe 140 inhibits scalding and carrageenan oedema for more than four and six hours, respectively. Based on its potency against actions of endogenously generated kinins Hoe 140 is appropriate to investigate the role of kinins in human inflammatory diseases.

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