• Eur. J. Heart Fail. · Jun 2007

    Comparative Study

    Direct comparison of transcardiac difference between brain natriuretic peptide (BNP) and N-terminal pro-BNP in patients with chronic heart failure.

    • Takayoshi Tsutamoto, Hiroshi Sakai, Chitose Ishikawa, Masanori Fujii, Toshinari Tanaka, Takashi Yamamoto, Hiroyuki Takashima, Masato Ohnishi, Atsuyuki Wada, and Minoru Horie.
    • Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Tsukinowa, Seta, Otsu 520-2192, Japan. tutamoto@belle.shiga-med.ac.jp <tutamoto@belle.shiga-med.ac.jp>
    • Eur. J. Heart Fail. 2007 Jun 1;9(6-7):667-73.

    BackgroundDirect comparison of transcardiac increase in brain natriuretic peptide (BNP) and NT-pro-BNP has not been performed previously.AimsTo evaluate the relation between BNP and NT-pro-BNP secretion, plasma levels and renal function.MethodsWe measured the plasma levels of BNP and NT-pro-BNP in the aortic root and coronary sinus in 326 consecutive patients with chronic heart failure (CHF). Patients were divided into two groups [group I: estimated glomerular filtration rate (eGFR)>or=60 mL/min and group II: eGFR<60 mL/min].ResultsThe molar level of the transcardiac increase in NT-pro-BNP is lower than that of BNP. There were no differences in haemodynamics or the transcardiac gradient of BNP and NT-pro-BNP between group I and group II. The molar ratio of the plasma NT-pro-BNP to BNP was significantly higher in group II than in group I. By stepwise multivariate analyses, not only the left ventricular (LV) ejection fraction and LV end-diastolic pressure, but also eGFR, LV mass index (LVMI) and haemoglobin were independent predictors of plasma NT-pro-BNP and BNP.ConclusionThe molar level of the transcardiac increase in NT-pro-BNP is lower than that of BNP; however, the influence of renal function on plasma NT-pro-BNP is greater than that on BNP.

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