• Eur. J. Pharmacol. · Sep 2011

    Review

    TRPA1 ion channel in the spinal dorsal horn as a therapeutic target in central pain hypersensitivity and cutaneous neurogenic inflammation.

    • Antti Pertovaara and Ari Koivisto.
    • Institute of Biomedicine/Physiology, POB 63, University of Helsinki, 00014 Helsinki, Finland. antti.pertovaara@helsinki.fi
    • Eur. J. Pharmacol. 2011 Sep 1;666(1-3):1-4.

    AbstractTransient receptor potential ankyrin 1 (TRPA1) is a non-selective, calcium permeable cation channel expressed by a subpopulation of primary afferent nociceptive nerve fibers. On peripheral nerve endings, TRPA1 channel contributes to transduction of chemical and physical stimuli, whereas on the central endings in the spinal dorsal horn, which is the topic of this brief review, it regulates glutamatergic transmission. Blockade of the spinal TRPA1 channel has attenuated mechanical pain hypersensitivity particularly to low-intensity stimulation in various pathophysiological conditions, whereas blockade of the TRPA1 channel-mediated regulation of transmission failed to influence baseline pain behavior in healthy control animals. Additionally, blockade of the spinal TRPA1 channel reduced cutaneous neurogenic inflammation, presumably by decreasing drive of spinal interneurons that induce a proinflammatory dorsal root reflex. The spinal TRPA1 channel provides a promising target for development of a selective disease-modifying therapy for central pain hypersensitivity. Blockade of the spinal TRPA1 channel-mediated regulation of transmission may also attenuate cutaneous neurogenic inflammation.Copyright © 2011 Elsevier B.V. All rights reserved.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…