• BMC research notes · Jan 2015

    Is there a role for monocyte chemoattractant protein-1 in delirium? Novel observations in elderly hip fracture patients.

    • Kjersti Skrede, Torgeir Bruun Wyller, Leiv Otto Watne, Ingebjørg Seljeflot, and Vibeke Juliebø.
    • Oslo Delirium Research Group, Oslo, Norway. kjersti.skrede@so-hf.no.
    • BMC Res Notes. 2015 Jan 1;8:186.

    BackgroundDelirium is common, associated with poor outcome, but its pathophysiology remains obscure. The aim of the present study was to study a possible role of monocyte chemoattractant protein-1 (MCP-1) in the development of delirium.FindingsA prospective cohort of 19 hip fracture patients (median age 83 years) were screened for delirium daily by validated methods. MCP-1 was measured on arrival and postoperatively. The number of patients with a raise in MCP-1 was statistically significantly higher in the group with delirium in the postoperative phase compared to the no-delirium group (5/6 vs. 1/7, p = .03).ConclusionsMCP-1 might play a role in the development of delirium.

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