• Afrothite Kotsakis, Anna-Theresa Lobos, Christopher Parshuram, Jonathan Gilleland, Rose Gaiteiro, Hadi Mohseni-Bod, Ram Singh, Desmond Bohn, and Ontario Pediatric Critical Care Response Team Collaborative.
• FRCP(C), Hospital for Sick Children, Department of Critical Care Medicine, 555 University Ave Toronto, Ontario, Canada M5G 1X8. afrothite.kotsakis@sickkids.ca
• Pediatrics. 2011 Jul 1;128(1):72-8.

ObjectivesThis is the first large multicenter study to examine the effectiveness of a pediatric rapid response system (PRRS). The primary objective was to determine the effect of a PRRS using a physician-led team on the rate of actual cardiopulmonary arrests, defined as an event requiring chest compressions, epinephrine, or positive pressure ventilation. The secondary objectives were to determine the effect of PRRSs on the rate of PICU readmission within 48 hours of discharge and PICU mortality after readmission and urgent PICU admission.MethodsA PRRS was developed, implemented, and evaluated in a standardized manner across 4 pediatric academic centers in Ontario, Canada. The team responded to activations for inpatients and followed patients discharged from the PICU for 48 hours. A 2-year, prospective, observational study was conducted after implementation, and outcomes were compared with data collected 2 years before implementation.ResultsAfter PRRS implementation, there were 55 963 hospital admissions and a team activation rate of 44 per 1000 hospital admissions. There were 7302 patients followed after PICU discharge. Implementation of the PRRS was not associated with a reduction in the rate of actual cardiopulmonary arrests (1.9 vs 1.8 per 1000 hospital admissions; P=.68) or PICU mortality after urgent admission (1.3 vs 1.1 per 1000 hospital admissions; P=.25). There was a reduction in the PICU mortality rate after readmission (0.3 vs 0.1 death per 1000 hospital admissions; P=.05).ConclusionThe standardized implementation of a multicenter PRRS was associated with a decrease in the rate of PICU mortality after readmission but not actual cardiopulmonary arrests.Copyright © 2011 by the American Academy of Pediatrics.

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