• Tyler Cheung, Miriam Nuño, Matilde Hoffman, Maya Katz, Camilla Kilbane, Ron Alterman, and Michele Tagliati.
• Department of Neurology, Cedars-Sinai Medical Center, 8730 Alden Drive, Thalians E-238, Los Angeles, CA 90048, USA.
• Brain Stimul. 2013 Sep 1;6(5):746-51.

BackgroundDeep brain stimulation (DBS) is an effective therapy for advanced movement disorders, but its optimal use is still controversial. One factor that could play a role in the proper delivery of therapeutic stimulation by current DBS devices is the variability of the impedance at the interface between the electrode surface and surrounding tissue.ObjectiveTo analyze variability and trends in the impedance of chronically-implanted DBS electrodes in subjects with movement disorders.MethodsWe reviewed impedance values from medical records of DBS patients at an academic tertiary-care movement disorders center. The standard deviation of data recorded within individual subjects and single contacts were used as measures of longitudinal impedance variability. A generalized linear mixed model (GLMM) determined if a number of effects had significant influences on impedance.ResultsWe analyzed 2863 impedance measurements from 94 subjects. Median variability, for subjects with follow-up from 6 months to 5 years (n = 77), was 194 Ω for individual subjects and 141 Ω for individual contacts, with a range spanning from 18 to over 600 Ω. The GLMM, incorporating all subjects (n = 94), identified time, electrical activity, implanted target, contact position on the electrode and side of implantation as significant predictors of impedance. Age and disease duration at surgery, gender or ethnicity were not significant predictors.ConclusionsOur analysis suggests that a significant amount of impedance variability can be expected in chronically implanted DBS electrodes and indicates a number of factors with possible predictive value. Further studies are needed to link impedance characteristics to clinical outcomes.Copyright © 2013 Elsevier Inc. All rights reserved.

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