• Pharmacotherapy · Feb 2004

    Randomized Controlled Trial Comparative Study Clinical Trial

    The antipyretic effect of ibuprofen and acetaminophen in children.

    • Haney Wahba.
    • Indiana Regional Medical Center, and the Department of Family Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
    • Pharmacotherapy. 2004 Feb 1;24(2):280-4.

    ObjectiveTo determine whether evidence in the medical literature supports ibuprofen or acetaminophen for reducing fever in children.MethodsBoth MEDLINE and the Science Citation Index were searched using various medical subject headings for all articles published worldwide from 1966-2000. The language of publication was not restricted.ResultsInitially, 4132 articles were found that dealt with either ibuprofen or acetaminophen. Limiting these articles to humans and children, and cross-referencing with the Science Citation Index resulted in 68 articles; 22 satisfied the inclusion criteria and were further assessed for validity, design, and methods of reporting data.ConclusionAcetaminophen and ibuprofen have equal tolerability. Acetaminophen produced a greater body temperature reduction at 0.5 hour after intervention compared with ibuprofen. However, ibuprofen provides a longer duration of antipyretic effect than acetaminophen 4 hours after intervention, and the initial temperature decrement lasts longer.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…