• Clin. Pharmacol. Ther. · Jun 1988

    Clinical Trial Controlled Clinical Trial

    Analgesic effect of picenadol, codeine, and placebo in patients with postoperative pain.

    • R L Brunelle, R E George, A Sunshine, and W D Hammonds.
    • Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285.
    • Clin. Pharmacol. Ther. 1988 Jun 1;43(6):663-7.

    AbstractA double-blind, parallel study was conducted to evaluate the analgesic effect and safety of a single 25 mg oral dose of picenadol, a centrally acting analgesic, and to compare it with a 60 mg dose of codeine and a placebo in patients with postoperative pain. Two sites using similar protocols enrolled a total of 178 inpatients with postoperative pain. Pain intensity, relief, and adverse experiences were then measured for up to 6 hours after administration of the test medications. Both picenadol and codeine were significantly more effective than placebo in reducing pain intensity (mean sum of pain intensity difference scores: picenadol 5.21, codeine 5.19, and placebo 2.82) and increasing total relief (mean total pain relief: picenadol 10.21, codeine 11.07, and placebo 6.96). Adverse experience profiles were similar among the three treatment groups.

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