• J Craniomaxillofac Surg · Dec 2012

    Randomized Controlled Trial Comparative Study

    Comparative analysis of preemptive analgesic effect of tramadol chlorhydrate and nimesulide following third molar surgery.

    • Fábio Andrey da Costa Araújo, Thiago de Santana Santos, Hécio Henrique Araújo de Morais, José Rodrigues Laureano Filho, Emanuel Dias de Oliveira E Silva, and Ricardo José Holanda Vasconcellos.
    • General Newton Cavalcante, 1651 Tabatinga, CEP: 54753e220 Camaragibe, Pernambuco, Brazil. fabioandrey.bmf@hotmail.com
    • J Craniomaxillofac Surg. 2012 Dec 1;40(8):e346-9.

    AbstractThe aim of this prospective, randomized, controlled, paired trial was to perform a comparative analysis of the preemptive analgesic effect of nimesulide and tramadol chlorhydrate during third molar surgery. The study was carried out between March and November 2009, involving 94 operations in 47 male and female patients with bilateral impacted lower third molars in comparable positions. The sample was divided into two groups. Group A received an oral dose of 100 mg of nimesulide 1 h prior to surgery. Group B received an oral dose of 100 mg of tramadol chlorhydrate 1 h prior to surgery. The following aspects were evaluated in the postoperative period: adverse effects of the drugs; amount of rescue medication used (acetaminophen 750 mg); and pain 5, 6, 24, 36, 48, 60, 72 and 84 h after surgery using a visual analog pain scale. Peak pain occurred 5 h after surgery in both groups, with a mean pain score of 2.3 in Group A and 3.0 in Group B; this difference did not achieve statistical significance (p > 0.141). Based on the sample studied, nimesulide and tramadol chlorhydrate demonstrate similar preemptive analgesic effects when used in lower third molar surgeries.Copyright © 2012 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

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