Influence of enzyme inducing antiepileptic drugs on the

Epilepsy research · Mar 2011

Clinical Trial

Influence of enzyme inducing antiepileptic drugs on the pharmacokinetics of levetiracetam in patients with epilepsy.

To assess whether levetiracetam elimination is influenced by enzyme inducing antiepileptic drugs (EIAEDs), serum levetiracetam levels were determined at frequent intervals after a single oral 1000mg dose in 15 subjects co-medicated with EIAEDs and 15 matched controls. The EIAED group showed a higher levetiracetam oral clearance (p=0.01) and a shorter half-life (p=0.02) than controls. Although the magnitude of interaction is relatively modest, it could have clinical significance for some patients.

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- Priscila Freitas-Lima, Veriano Alexandre, Leonardo Regis Leira Pereira, Fausto Feletti, Emilio Perucca, and Americo Ceiki Sakamoto.
- Ribeirão Preto School of Medicine, University of São Paulo, 14049-900 Ribeirão Preto, Brazil. priscilalima@usp.br
- Epilepsy Res. 2011 Mar 1;94(1-2):117-20.
AbstractTo assess whether levetiracetam elimination is influenced by enzyme inducing antiepileptic drugs (EIAEDs), serum levetiracetam levels were determined at frequent intervals after a single oral 1000mg dose in 15 subjects co-medicated with EIAEDs and 15 matched controls. The EIAED group showed a higher levetiracetam oral clearance (p=0.01) and a shorter half-life (p=0.02) than controls. Although the magnitude of interaction is relatively modest, it could have clinical significance for some patients.Copyright © 2011 Elsevier B.V. All rights reserved.

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Influence of enzyme inducing antiepileptic drugs on the pharmacokinetics of levetiracetam in patients with epilepsy.

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