• Epilepsy research · Mar 2011

    Clinical Trial

    Influence of enzyme inducing antiepileptic drugs on the pharmacokinetics of levetiracetam in patients with epilepsy.

    • Priscila Freitas-Lima, Veriano Alexandre, Leonardo Regis Leira Pereira, Fausto Feletti, Emilio Perucca, and Americo Ceiki Sakamoto.
    • Ribeirão Preto School of Medicine, University of São Paulo, 14049-900 Ribeirão Preto, Brazil. priscilalima@usp.br
    • Epilepsy Res. 2011 Mar 1;94(1-2):117-20.

    AbstractTo assess whether levetiracetam elimination is influenced by enzyme inducing antiepileptic drugs (EIAEDs), serum levetiracetam levels were determined at frequent intervals after a single oral 1000mg dose in 15 subjects co-medicated with EIAEDs and 15 matched controls. The EIAED group showed a higher levetiracetam oral clearance (p=0.01) and a shorter half-life (p=0.02) than controls. Although the magnitude of interaction is relatively modest, it could have clinical significance for some patients.Copyright © 2011 Elsevier B.V. All rights reserved.

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