• Anesthesiol Clin North America · Dec 2003

    Review

    Spinal analgesics.

    • Hollie Nguyen, Jason E Garber, and Samuel J Hassenbusch.
    • Department of Neurosurgery, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Box 442, Houston, TX 77030, USA.
    • Anesthesiol Clin North America. 2003 Dec 1;21(4):805-16.

    AbstractThe important issues to be emphasized when considering the intrathecal administration of novel analgesics are their proven antinociceptive effect, safety (short- and long-term effects on the spinal cord and potential toxicities), stability in shelf solution and at body temperature by itself, or in combination with other drugs in spinal fluid, compatibility with a long-term spinal infusion pump, whether they are of sufficiently high potency and solubility to be used in the finite volume of an implanted infusion pump, and if a pharmaceutical company is willing to invest the immense resources needed for US Food and Drug Administration approval and subsequent commercial development.

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