• Curr Psychiatry Rep · Dec 2013

    Review

    Pain and depression: an integrative review of neurobiological and psychological factors.

    • Jenna Goesling, Daniel J Clauw, and Afton L Hassett.
    • Department of Anesthesiology, Back & Pain Center, University of Michigan, Burlington Building 1, Suite 100, 325 E. Eisenhower Parkway, Ann Arbor, MI, 48108, USA, jennagoe@med.umich.edu.
    • Curr Psychiatry Rep. 2013 Dec 1;15(12):421.

    AbstractThe comorbidity of pain and depression has been well established in the literature and is associated with a greater burden to the individual and society than either condition alone. The relationship between pain and depression is quite complex and multiple factors must be considered when trying to disentangle the pain-depression link including shared neurobiology, precipitating environmental factors and cognitive influences. This article aims to provide an overview of the leading neurobiological and psychosocial theories that have advanced our understanding of the link between pain and depression. To this end we describe the shared neurobiological mechanisms in the brain thought to explain the overlap and consider psychological processes and how they inform a cognitive behavioral model. The article also provides an overview of the evidence based treatment for comorbid pain and depression.

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