• Der Nervenarzt · Oct 2006

    Randomized Controlled Trial

    [Central and peripheral deafferent pain: therapy with repetitive transcranial magnetic stimulation].

    • K Irlbacher, J Kuhnert, S Röricht, B U Meyer, and S A Brandt.
    • Neurologische Klinik, Charité Centrum für Neurologie, Neurochirurgie und Psychiatrie, Charitéplatz 1, 10117, Berlin. stephan.brandt@charite.de
    • Nervenarzt. 2006 Oct 1;77(10):1196, 1198-203.

    BackgroundThis study evaluates the effects of repeated sessions of low- and high-frequency repetitive transcranial magnetic stimulation (rTMS) over the primary motor cortex on central and phantom limb pain.MethodsTwenty seven patients with central (n=13) and phantom limb (n=14) pain participated in a blind, randomised placebo-controlled study comparing the effect of 1-Hz and 5-Hz rTMS with sham stimulation. Each treatment block consisted of a 5-day baseline phase, a 5-day therapy phase, and an 18-day washout phase. In the therapy phase, 500 stimuli were applied in the particular frequency at about the same time on each day.ResultsA reduction in pain immediately after stimulation was observed in all therapy groups. This effect was similar for all treatment conditions, including sham stimulation. No significant long-term effects of rTMS on pain intensity or mood were observed.ConclusionAt present, rTMS can not be recommended as a standard therapy for central and phantom limb pain.

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