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- Gabor Csifcsak, Michael A Nitsche, Ulf Baumgärtner, Walter Paulus, Rolf-Detlef Treede, and Andrea Antal.
- Department of Clinical Neurophysiology, Georg-August University, Göttingen, Germany.
- Neuroreport. 2009 Aug 5;20(12):1051-5.
AbstractIn an earlier study, we reported the antinociceptive effects of a special repetitive transcranial magnetic stimulation paradigm: continuous theta-burst stimulation (cTBS), when applied to human motor cortex. Here, we investigated whether the reduced subjective pain perception of 10 healthy individuals could be measured by changes in laser-evoked potentials, a reflection of pain related activations in the operculoinsular and midcingulate cortex. To minimize the effect of habituation during repeated laser stimulation, a bioadaptive design was used. However, both pain ratings and laser-evoked potential amplitudes were reduced after real and sham cTBS. When compared with sham stimulation, cTBS resulted in a significantly greater diminution of pain ratings and N2-P2 amplitudes on the hand contralateral to the site of motor cortex stimulation.
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