• Joseph P Mathew, Hilary P Grocott, James R McCurdy, Lian K Ti, Davis R Duane RD, Daniel T Laskowitz, Mihai V Podgoreanu, Madhav Swaminathan, John Lynch, Mark Stafford-Smith, William D White, and Mark F Newman.
• Division of Cardiothoracic Anesthesiology and Critical Care Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA. mathe014@mc.duke.edu
• J. Cardiothorac. Vasc. Anesth. 2005 Jun 1; 19 (3): 294-9.

ObjectiveThe purpose of this study was to determine if patients receiving statin therapy before coronary artery bypass grafting surgery would have less cognitive dysfunction after cardiopulmonary bypass as a consequence of a diminished inflammatory response.DesignRetrospective observational study of patients undergoing coronary artery bypass grafting surgery.SettingReferral center for cardiothoracic surgery at a university hospital.ParticipantsFour hundred forty patients undergoing coronary artery bypass grafting surgery with cardiopulmonary bypass.InterventionsNone.Measurements And Main ResultsThirty-five percent of patients received statins in the preoperative period. Multivariable analysis revealed no effect of preoperative statin therapy on cognitive function (p = 0.67). Post hoc analysis revealed that statin therapy at hospital discharge was associated with less improvement in cognitive performance at 6 weeks after surgery (p = 0.011). No significant differences were found between statin therapy groups in either range or maximum value of any of the cytokines (p > 0.05).ConclusionsPreoperative statin therapy did not decrease the inflammatory response to cardiopulmonary bypass or the cognitive dysfunction commonly seen after cardiac surgery.

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