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Experimental neurology · Nov 2003
Comparative StudyDevelopment of HSV-mediated gene transfer for the treatment of chronic pain.
- Marina Mata, Joseph Glorioso, and David J Fink.
- Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.
- Exp. Neurol. 2003 Nov 1;184 Suppl 1:S25-9.
AbstractChronic pain is often difficult to treat effectively. We have exploited the high affinity of herpes simplex virus (HSV) for peripheral sensory neurons to create HSV-based vectors for the treatment of chronic pain. We have demonstrated that an HSV-based vector expressing proenkephalin reduces pain-related responses in rodent models of inflammatory pain, neuropathic pain, and pain resulting from cancer in bone. A human trial has been proposed.
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