• A M Messing-Jünger, J Marzog, G Wöbker, M Sabel, and W J Bock.
• Neurosurgical Clinic, University Hospital, Heinrich-Heine-University, Düsseldorf, Germany. Messing-Juenger@med.uni-duesseldorf.de
• Zentralbl. Neurochir. 2003 Jan 1;64(4):171-7.

ObjectThe goal of this study was to evaluate the therapeutic role of decompressive craniectomy in severe brain injury.Methods And ResultsBetween 1996 and 1998 we treated 87 patients with severe brain injury (GCS 3-8) in our department. In 70 cases follow up data could be obtained. Mean age was 49 years (range 1-79). Initial CT scans of all patients demonstrated diffuse brain injury with generalised brain swelling and/or mass lesion. In 51 of these patients uni (n=40)- or bilateral (n=11) decompressive craniectomy was performed initially or secondarily after failure of standard treatment. In a retrospective analysis we performed statistical tests of the follow-up group. The mortality rate did not show a significant difference between the two treatment groups (p=0.802) with a slight advantage for the decompression. The log-rank-test demonstrated a non-significant improvement of the survival time for decompressed patients (p=0.632). Secondary decompression showed a significantly better survival rate and time compared to primary decompression. In all 7 pediatric cases (1-16 yrs) we performed craniectomy. 2 of them died immediately post emergency operation, 5 survived with good outcome (1 LOF).ConclusionsA slight, but non-significant benefit could be demonstrated after decompressive craniectomy in the whole patient population. In young patients decompression seems to have a more positive influence on outcome and survival.

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