• Anesthesiology clinics · Jun 2014

    Review

    Long-acting serotonin antagonist (Palonosetron) and the NK-1 receptor antagonists: does extended duration of action improve efficacy?

    • M Stephen Melton, Karen C Nielsen, Marcy Tucker, Stephen M Klein, and Tong J Gan.
    • Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA.
    • Anesthesiol Clin. 2014 Jun 1;32(2):505-16.

    AbstractIn a growing outpatient surgical population, postdischarge nausea and vomiting (PDNV) is unfortunately a common and costly anesthetic complication. Identification of risk factors for both postoperative nausea and vomiting and PDNV is the hallmark of prevention and management. New pharmacologic interventions with extended duration of action, including palonosetron and aprepritant, may prove to be more efficacious.Copyright © 2014 Elsevier Inc. All rights reserved.

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